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human osteosarcoma thymidine kinase deficient cell line 143b  (ATCC)
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ATCC human osteosarcoma thymidine kinase deficient cell line 143b
(a) Overview of the study including the development and validation of scMOCHA framework and large-scale discovery workflow for single-cell mtDNA variant analysis in human PBMC and BM samples. (b) Venn diagrams summarize the homoplasmic (purple), heteroplasmic (blue), and somatic (red) variants identified across PBMC and BM datasets. (c) Circos plots illustrate the genomic distribution and allele frequency (AF) of mtDNA variants across the mitochondrial genome in PBMC and BM. Tracks from outer to inner rings are: mitochondrial genome position (black), PhastCons100way conservation (yellow), population AF derived from gnomAD (black), sample frequency of homoplasmic variants (purple) and heteroplasmic variants (blue), the mitochondrial gene annotation map (middle), mean pseudobulk AF of homoplasmic variants (purple), heteroplasmic variants (blue), and somatic variants (red).
Human Osteosarcoma Thymidine Kinase Deficient Cell Line 143b, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human osteosarcoma thymidine kinase deficient cell line 143b - by Bioz Stars, 2026-11
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u2os  (ATCC)
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(a) Overview of the study including the development and validation of scMOCHA framework and large-scale discovery workflow for single-cell mtDNA variant analysis in human PBMC and BM samples. (b) Venn diagrams summarize the homoplasmic (purple), heteroplasmic (blue), and somatic (red) variants identified across PBMC and BM datasets. (c) Circos plots illustrate the genomic distribution and allele frequency (AF) of mtDNA variants across the mitochondrial genome in PBMC and BM. Tracks from outer to inner rings are: mitochondrial genome position (black), PhastCons100way conservation (yellow), population AF derived from gnomAD (black), sample frequency of homoplasmic variants (purple) and heteroplasmic variants (blue), the mitochondrial gene annotation map (middle), mean pseudobulk AF of homoplasmic variants (purple), heteroplasmic variants (blue), and somatic variants (red).
U2os, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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u2os - by Bioz Stars, 2026-11
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143b  (ATCC)
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ATCC 143b
(a) Overview of the study including the development and validation of scMOCHA framework and large-scale discovery workflow for single-cell mtDNA variant analysis in human PBMC and BM samples. (b) Venn diagrams summarize the homoplasmic (purple), heteroplasmic (blue), and somatic (red) variants identified across PBMC and BM datasets. (c) Circos plots illustrate the genomic distribution and allele frequency (AF) of mtDNA variants across the mitochondrial genome in PBMC and BM. Tracks from outer to inner rings are: mitochondrial genome position (black), PhastCons100way conservation (yellow), population AF derived from gnomAD (black), sample frequency of homoplasmic variants (purple) and heteroplasmic variants (blue), the mitochondrial gene annotation map (middle), mean pseudobulk AF of homoplasmic variants (purple), heteroplasmic variants (blue), and somatic variants (red).
143b, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cervical adenocarcinoma hela  (ATCC)
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(a) Overview of the study including the development and validation of scMOCHA framework and large-scale discovery workflow for single-cell mtDNA variant analysis in human PBMC and BM samples. (b) Venn diagrams summarize the homoplasmic (purple), heteroplasmic (blue), and somatic (red) variants identified across PBMC and BM datasets. (c) Circos plots illustrate the genomic distribution and allele frequency (AF) of mtDNA variants across the mitochondrial genome in PBMC and BM. Tracks from outer to inner rings are: mitochondrial genome position (black), PhastCons100way conservation (yellow), population AF derived from gnomAD (black), sample frequency of homoplasmic variants (purple) and heteroplasmic variants (blue), the mitochondrial gene annotation map (middle), mean pseudobulk AF of homoplasmic variants (purple), heteroplasmic variants (blue), and somatic variants (red).
Cervical Adenocarcinoma Hela, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cervical adenocarcinoma hela - by Bioz Stars, 2026-11
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human bone osteosarcoma cell line 143b  (ATCC)
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ATCC human bone osteosarcoma cell line 143b
(a) Overview of the study including the development and validation of scMOCHA framework and large-scale discovery workflow for single-cell mtDNA variant analysis in human PBMC and BM samples. (b) Venn diagrams summarize the homoplasmic (purple), heteroplasmic (blue), and somatic (red) variants identified across PBMC and BM datasets. (c) Circos plots illustrate the genomic distribution and allele frequency (AF) of mtDNA variants across the mitochondrial genome in PBMC and BM. Tracks from outer to inner rings are: mitochondrial genome position (black), PhastCons100way conservation (yellow), population AF derived from gnomAD (black), sample frequency of homoplasmic variants (purple) and heteroplasmic variants (blue), the mitochondrial gene annotation map (middle), mean pseudobulk AF of homoplasmic variants (purple), heteroplasmic variants (blue), and somatic variants (red).
Human Bone Osteosarcoma Cell Line 143b, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/143b/143B/us12648992-113-2-31
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human bone osteosarcoma cell line 143b - by Bioz Stars, 2026-11
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osteosarcoma 143b  (ATCC)
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ATCC osteosarcoma 143b
(a) Overview of the study including the development and validation of scMOCHA framework and large-scale discovery workflow for single-cell mtDNA variant analysis in human PBMC and BM samples. (b) Venn diagrams summarize the homoplasmic (purple), heteroplasmic (blue), and somatic (red) variants identified across PBMC and BM datasets. (c) Circos plots illustrate the genomic distribution and allele frequency (AF) of mtDNA variants across the mitochondrial genome in PBMC and BM. Tracks from outer to inner rings are: mitochondrial genome position (black), PhastCons100way conservation (yellow), population AF derived from gnomAD (black), sample frequency of homoplasmic variants (purple) and heteroplasmic variants (blue), the mitochondrial gene annotation map (middle), mean pseudobulk AF of homoplasmic variants (purple), heteroplasmic variants (blue), and somatic variants (red).
Osteosarcoma 143b, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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osteosarcoma 143b - by Bioz Stars, 2026-11
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human 143b osteosarcoma cells  (ATCC)
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ATCC human 143b osteosarcoma cells
(a) Overview of the study including the development and validation of scMOCHA framework and large-scale discovery workflow for single-cell mtDNA variant analysis in human PBMC and BM samples. (b) Venn diagrams summarize the homoplasmic (purple), heteroplasmic (blue), and somatic (red) variants identified across PBMC and BM datasets. (c) Circos plots illustrate the genomic distribution and allele frequency (AF) of mtDNA variants across the mitochondrial genome in PBMC and BM. Tracks from outer to inner rings are: mitochondrial genome position (black), PhastCons100way conservation (yellow), population AF derived from gnomAD (black), sample frequency of homoplasmic variants (purple) and heteroplasmic variants (blue), the mitochondrial gene annotation map (middle), mean pseudobulk AF of homoplasmic variants (purple), heteroplasmic variants (blue), and somatic variants (red).
Human 143b Osteosarcoma Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human 143b osteosarcoma cells - by Bioz Stars, 2026-11
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resource source identifier hos 143b atcc crl 8303 mg63 atcc crl  (ATCC)
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ATCC resource source identifier hos 143b atcc crl 8303 mg63 atcc crl
(a) Overview of the study including the development and validation of scMOCHA framework and large-scale discovery workflow for single-cell mtDNA variant analysis in human PBMC and BM samples. (b) Venn diagrams summarize the homoplasmic (purple), heteroplasmic (blue), and somatic (red) variants identified across PBMC and BM datasets. (c) Circos plots illustrate the genomic distribution and allele frequency (AF) of mtDNA variants across the mitochondrial genome in PBMC and BM. Tracks from outer to inner rings are: mitochondrial genome position (black), PhastCons100way conservation (yellow), population AF derived from gnomAD (black), sample frequency of homoplasmic variants (purple) and heteroplasmic variants (blue), the mitochondrial gene annotation map (middle), mean pseudobulk AF of homoplasmic variants (purple), heteroplasmic variants (blue), and somatic variants (red).
Resource Source Identifier Hos 143b Atcc Crl 8303 Mg63 Atcc Crl, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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resource source identifier hos 143b atcc crl 8303 mg63 atcc crl - by Bioz Stars, 2026-11
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cell culture human os cell lines 143b  (ATCC)
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ATCC cell culture human os cell lines 143b
(a) Overview of the study including the development and validation of scMOCHA framework and large-scale discovery workflow for single-cell mtDNA variant analysis in human PBMC and BM samples. (b) Venn diagrams summarize the homoplasmic (purple), heteroplasmic (blue), and somatic (red) variants identified across PBMC and BM datasets. (c) Circos plots illustrate the genomic distribution and allele frequency (AF) of mtDNA variants across the mitochondrial genome in PBMC and BM. Tracks from outer to inner rings are: mitochondrial genome position (black), PhastCons100way conservation (yellow), population AF derived from gnomAD (black), sample frequency of homoplasmic variants (purple) and heteroplasmic variants (blue), the mitochondrial gene annotation map (middle), mean pseudobulk AF of homoplasmic variants (purple), heteroplasmic variants (blue), and somatic variants (red).
Cell Culture Human Os Cell Lines 143b, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/143b/143B/pm42178546-95-1-22
Average 97 stars, based on 1 article reviews
cell culture human os cell lines 143b - by Bioz Stars, 2026-11
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(a) Overview of the study including the development and validation of scMOCHA framework and large-scale discovery workflow for single-cell mtDNA variant analysis in human PBMC and BM samples. (b) Venn diagrams summarize the homoplasmic (purple), heteroplasmic (blue), and somatic (red) variants identified across PBMC and BM datasets. (c) Circos plots illustrate the genomic distribution and allele frequency (AF) of mtDNA variants across the mitochondrial genome in PBMC and BM. Tracks from outer to inner rings are: mitochondrial genome position (black), PhastCons100way conservation (yellow), population AF derived from gnomAD (black), sample frequency of homoplasmic variants (purple) and heteroplasmic variants (blue), the mitochondrial gene annotation map (middle), mean pseudobulk AF of homoplasmic variants (purple), heteroplasmic variants (blue), and somatic variants (red).

Journal: bioRxiv

Article Title: Single-cell variant landscape of the human mitochondrial genome reveals cell type-specific functions and disease mechanisms

doi: 10.64898/2026.10.11.758340

Figure Lengend Snippet: (a) Overview of the study including the development and validation of scMOCHA framework and large-scale discovery workflow for single-cell mtDNA variant analysis in human PBMC and BM samples. (b) Venn diagrams summarize the homoplasmic (purple), heteroplasmic (blue), and somatic (red) variants identified across PBMC and BM datasets. (c) Circos plots illustrate the genomic distribution and allele frequency (AF) of mtDNA variants across the mitochondrial genome in PBMC and BM. Tracks from outer to inner rings are: mitochondrial genome position (black), PhastCons100way conservation (yellow), population AF derived from gnomAD (black), sample frequency of homoplasmic variants (purple) and heteroplasmic variants (blue), the mitochondrial gene annotation map (middle), mean pseudobulk AF of homoplasmic variants (purple), heteroplasmic variants (blue), and somatic variants (red).

Article Snippet: The human osteosarcoma thymidine kinase-deficient cell line 143B(TK − ) (ATCC CRL-8303) and human embryonic kidney HEK293 cells were maintained in Dulbecco’s Modified Eagle Medium GlutaMAX (DMEM; Thermo Fisher Scientific, 10569044) containing high glucose (4.5 g/L) and sodium pyruvate (110 mg/L), supplemented with 1% non-essential amino acids (NEAA) and 10% fetal bovine serum (FBS).

Techniques: Biomarker Discovery, Single Cell, Variant Assay, Analysis, Derivative Assay